TB-500 (Thymosin Beta-4) | Product Description
TB-500 (Thymosin Beta-4) | Introduction
TB-500 refers to research-grade thymosin β4 (timbetasin), used in RUO models to probe cytoskeletal signaling, motility, and matrix remodeling. Typical readouts include actin dynamics, focal-adhesion markers, and migration/closure assays. Not intended for diagnostic or therapeutic use.
- Actin-binding/cytoskeletal signaling
- Cell migration & wound-closure models
- Matrix deposition and remodeling markers
TB-500 | Molecular Identity & Composition
| Name | TB-500 (Thymosin Beta-4; Thymosin β4 Acetate) |
| Synonyms | Thymosin β4; Timbetasin; Tβ4; TB-500 |
| Sequence | Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser |
| Molecular Formula | C212H350N56O78S |
| Molecular Weight | ~4963.5 g/mol |
| CAS Number | 77591-33-4 |
| Appearance | White to off-white lyophilized powder |
| Solubility | Soluble in sterile or bacteriostatic water |
| Purity | ≥99% (HPLC), lot-specific |
| Storage Guidelines | • Lyophilized: ≤0°F (–18°C), dry, protected from light/moisture • Reconstituted: 36–46°F (2–8°C); short-term only • Long-Term: Store dry at ≤−20°C; avoid freeze–thaw |
LuvionBio Quality Advantage
- Purity & Identity: ≥99% | HPLC & MS validated
- Endotoxin & Sterility: <0.05 EU/mg | Third-party verified
- Stability & Process: Controlled-nucleation lyophilization | Stability-focused procedures
- Formulation & QA: PhD-formulated | GMP / ISO-aligned manufacturing
- Packaging: Luxe Fridge-Ready Box
Category Overview | Tissue Remodeling & Protein Function
Tissue-remodeling peptides are used in RUO systems to study how cells organize cytoskeleton and matrix—migration, adhesion, and protein-network balance. These models help profile dynamic protein function under strain, injury, or growth conditions.
Exciting Areas of Study
- Actin turnover, lamellipodia/filopodia dynamics
- ECM production and deposition assays
- Motility, closure, and invasion models
- Cytoskeletal signaling cross-talk (FAK, Rho/ROCK)
Research Applications
- Quantify migration/closure kinetics in vitro
- Probe protein–matrix signaling balance
- Benchmark remodeling signatures vs. controls
TB-500 | Research Modeling & Applications
- Map actin-binding effects on cytoskeletal architecture
- Evaluate matrix remodeling and adhesion markers
- Compare motility phenotypes across stressors
Research Use Disclaimer
This product is intended solely for laboratory research purposes and is not suitable for human, animal, or household use. Researchers must follow institutional safety protocols. See our Terms & Conditions and Research Compliance Disclaimers for details.

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